{"id":1494,"date":"2023-05-18T12:59:13","date_gmt":"2023-05-18T17:59:13","guid":{"rendered":"https:\/\/pdr-separations.com\/?p=1494"},"modified":"2023-05-22T14:09:18","modified_gmt":"2023-05-22T19:09:18","slug":"decon-smb-2023-05-17","status":"publish","type":"post","link":"https:\/\/pdr-separations.com\/?p=1494","title":{"rendered":"Decon-SMB- A large pharmaceutical company manufacturing active pharmaceutical ingredients (API)"},"content":{"rendered":"\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-6c7bba7e wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong>PROBLEM<\/strong><\/h2>\n\n\n\n<pre class=\"wp-block-preformatted\">The company was having difficulty with isolating and purifying trace impurities in APIs for the identification and characterization required by regulatory agencies.<\/pre>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\" id=\"block-1a4c3a28-c6af-4e7e-a12e-47e90f839061\"><strong>GOALS\/SOLUTIONS<\/strong><\/h3>\n\n\n\n<p>PDR-Separations was contracted to install a spectral deconvolution system on a pilot-scale SMB system.<\/p>\n\n\n\n<p>The customer wanted to isolate trace impurities in APIs for proper analysis and characterization along with making short runs using very little time to develop methods.<\/p>\n\n\n\n<p>PDR-Separations installed a flow cell before the recycling pump and connected the flow cell to a spectrometer and light source via fiber optic cables.<\/p>\n\n\n\n<p>PDR-Separations\u2019 software was installed and deconvolves the UV spectra and plots concentration of each component in real-time.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\"><strong>BENEFITS\/ACHIEVMENTS<\/strong><\/h3>\n\n\n\n<p>With concentration of each component plotted in real-time it is easy to see the desired minor peak and adjust SMB parameters to move that peak towards raffinate or extract ports.<\/p>\n\n\n\n<p>This technique, as opposed to extracting and analyzing multiple samples via HPLC which delayed purity results for an hour or more, resulted in much shorter run times.<\/p>\n\n\n\n<p>Method optimization is much faster and more deterministic. Results of each adjustment is clear within a few SMB cycles.<\/p>\n\n\n\n<p>The new system and procedures have increased throughput by at least 10 times and made many purifications possible that were unrealistic before due to the previous extended method optimization time.<\/p>\n\n\n\n<div class=\"wp-block-essential-blocks-button\"><div class=\"eb-parent-wrapper eb-parent-eb-button-m6fqsga \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-m6fqsga\"><div class=\"eb-button\"><a class=\"eb-button-anchor\" href=\"https:\/\/pdr-separations.com\/wp-content\/uploads\/Decon-SMB-2023-05-17.pdf\" target=\"_blank\" rel=\"noopener\">Download PDF<\/a><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-button\"><div class=\"eb-parent-wrapper eb-parent-eb-button-kblhtg0 \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-kblhtg0\"><div class=\"eb-button\"><a class=\"eb-button-anchor\" href=\"https:\/\/pdr-separations.com\/?page_id=1357\" rel=\"noopener\">Return to the Case Studies<\/a><\/div><\/div><\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PROBLEM The company was having difficulty with isolating and purifying trace impurities in APIs for the identification and characterization required by regulatory agencies. GOALS\/SOLUTIONS PDR-Separations was contracted to install a spectral deconvolution system on a pilot-scale SMB system. The customer wanted to isolate trace impurities in APIs for proper analysis and characterization along with making [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-1494","post","type-post","status-publish","format-standard","hentry","category-case-studies"],"_links":{"self":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1494"}],"version-history":[{"count":8,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1494\/revisions"}],"predecessor-version":[{"id":1556,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1494\/revisions\/1556"}],"wp:attachment":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}