{"id":1479,"date":"2023-05-18T12:45:09","date_gmt":"2023-05-18T17:45:09","guid":{"rendered":"https:\/\/pdr-separations.com\/?p=1479"},"modified":"2023-05-22T14:07:54","modified_gmt":"2023-05-22T19:07:54","slug":"autoprep-2023-05-17","status":"publish","type":"post","link":"https:\/\/pdr-separations.com\/?p=1479","title":{"rendered":"AutoPREP-SD1- A Fast-response purification lab supporting medicinal chemistry inside a large pharmaceutical company"},"content":{"rendered":"\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-6c7bba7e wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-medium-font-size\">PROBLEM<\/h2>\n\n\n\n<pre class=\"wp-block-preformatted\">The lab was struggling to process material quickly enough using 2 mid-scale preparative HPLC purification systems. Each system included 3 200 mL\/min SD1 pumps (2 for eluent mixing and 1 for injection).<\/pre>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\" id=\"block-1a4c3a28-c6af-4e7e-a12e-47e90f839061\">GOALS\/SOLUTIONS<\/h3>\n\n\n\n<p>The company\u2019s lab manager needed to increase throughput and make systems easier to setup and use.<\/p>\n\n\n\n<p>After discussions with PDR-Separations the company decided to have PDR-Separations reconfigure the 2 systems to operate with PDR-Separations\u2019 AutoPREP automation software and Collection modules.<\/p>\n\n\n\n<p>The reconfigured systems now run automated methods that allow all parameters to be changed while a method is running so close stacking of maximum volume injections can be tweaked as equilibrium is reached over first few hours of operation.<\/p>\n\n\n\n<p>This feature is very beneficial to reduce solvent consumption while running high flow rates and reducing run times. Systems now run 24\/7 and throughput has increased noticeably.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\">BENEFITS\/ACHIEVMENTS<\/h3>\n\n\n\n<p>The results were impressive, samples are processed faster and more deterministically. Staff has more time for other tasks because PDR-Separations\u2019 lab automation software is easy to use and does not require much attention.<\/p>\n\n\n\n<p>By operating the automated systems 24\/7 the Lab now processes 8 times more material, staff is no longer overloaded, is able to do research, attend meetings and write reports.<\/p>\n\n\n\n<p>The combination of a new operating procedure, much better automation software, and enabling automation hardware required a few months to adapt but everyone is much happier now, including upper management.<\/p>\n\n\n\n<p>The cumulative benefit of improved procedures with better automation software and automation hardware was significant resulting in a much better ROI than expected.<\/p>\n\n\n\n<div class=\"wp-block-essential-blocks-button\"><div class=\"eb-parent-wrapper eb-parent-eb-button-m6fqsga \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-m6fqsga\"><div class=\"eb-button\"><a class=\"eb-button-anchor\" href=\"https:\/\/pdr-separations.com\/wp-content\/uploads\/AutoPREP-2023-05-17.pdf\" target=\"_blank\" rel=\"noopener\">Download PDF<\/a><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-button\"><div class=\"eb-parent-wrapper eb-parent-eb-button-7wzbydk \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-7wzbydk\"><div class=\"eb-button\"><a class=\"eb-button-anchor\" href=\"https:\/\/pdr-separations.com\/?page_id=1357\" rel=\"noopener\">Return to Case Studies<\/a><\/div><\/div><\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PROBLEM The lab was struggling to process material quickly enough using 2 mid-scale preparative HPLC purification systems. Each system included 3 200 mL\/min SD1 pumps (2 for eluent mixing and 1 for injection). GOALS\/SOLUTIONS The company\u2019s lab manager needed to increase throughput and make systems easier to setup and use. After discussions with PDR-Separations the [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-1479","post","type-post","status-publish","format-standard","hentry","category-case-studies"],"_links":{"self":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1479"}],"version-history":[{"count":6,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1479\/revisions"}],"predecessor-version":[{"id":1552,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1479\/revisions\/1552"}],"wp:attachment":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}