{"id":1477,"date":"2023-05-18T12:42:29","date_gmt":"2023-05-18T17:42:29","guid":{"rendered":"https:\/\/pdr-separations.com\/?p=1477"},"modified":"2023-05-22T14:08:19","modified_gmt":"2023-05-22T19:08:19","slug":"autolab-ccc-2023-05-17","status":"publish","type":"post","link":"https:\/\/pdr-separations.com\/?p=1477","title":{"rendered":"AutoLAB-CCC- A fast-response purification lab supporting medicinal chemistry inside a large pharmaceutical company"},"content":{"rendered":"\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-02684f8b wp-block-columns-is-layout-flex\" style=\"margin-top:0px;margin-bottom:0px;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong>PROBLEM<\/strong><\/h2>\n\n\n\n<pre class=\"wp-block-preformatted\">The lab was struggling to process material quickly enough using CounterCurrent Chromatography (CCC) and the HPLC-centric staff was reluctant to use CCC.<\/pre>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\" id=\"block-1a4c3a28-c6af-4e7e-a12e-47e90f839061\"><strong>GOALS\/SOLUTIONS<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The company\u2019s lab manager needed to increase throughput for CounterCurrent Chromatography (CCC) purifications.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">After discussions with PDR-Separations the company decided to have PDR-Separations reconfigure the company\u2019s Dynamic Extractions Spectrum dual CCC (analytical and semi-prep) system and install a larger 1L CCC from JCT, both to be operated with PDR-Separations\u2019 automation software and hardware modules.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The DE Spectrum dual CCC with 2 Agilent analytical pumps and DAD now runs automated method screening sequences, written by PDR-Separations, using PDR-Separations AutoMDS software and Gradient Mixer module.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Gradient Mixer module mixes upper and lower phases as needed. The DE Spectrum CCC can be changed automatically from analytical to semi-prep configuration to purify small amounts using PDR-Separations AutoPREP software with Injector\/Collector and Valve Control modules.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A new 1L CCC from JCT was installed and runs automated purification methods using PDR-Separations\u2019 AutoPREP software with an Injector\/Collector module inside a hood with pressurized upper and lower phase cylinders for extended operations.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\">B<strong>ENEFITS\/ACHIEVMENTS<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Material is now processed faster and more deterministically.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PDR-Separations\u2019 automation software is easy to use, does not require much attention, and is common to both systems.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Overall results show the lab now processes 6 times more material and staff is much happier. The combination of a new automated operating procedure, easy to use software, and enabling hardware treats the CCC as a column so operation is not much different from HPLC.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Staff feels more comfortable with CCC because now it is not necessary to understand CCC details to use CCC.<\/p>\n\n\n\n<div class=\"wp-block-essential-blocks-button\"><div class=\"eb-parent-wrapper eb-parent-eb-button-m6fqsga \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-m6fqsga\"><div class=\"eb-button\"><a class=\"eb-button-anchor\" href=\"https:\/\/pdr-separations.com\/wp-content\/uploads\/AutoLAB-CCC-2023-05-17.pdf\" target=\"_blank\" rel=\"noopener\">Download PDF<\/a><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-button\"><div class=\"eb-parent-wrapper eb-parent-eb-button-7wzbydk \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-7wzbydk\"><div class=\"eb-button\"><a class=\"eb-button-anchor\" href=\"https:\/\/pdr-separations.com\/?page_id=1357\" rel=\"noopener\">Return to Case Studies<\/a><\/div><\/div><\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PROBLEM The lab was struggling to process material quickly enough using CounterCurrent Chromatography (CCC) and the HPLC-centric staff was reluctant to use CCC. GOALS\/SOLUTIONS The company\u2019s lab manager needed to increase throughput for CounterCurrent Chromatography (CCC) purifications. After discussions with PDR-Separations the company decided to have PDR-Separations reconfigure the company\u2019s Dynamic Extractions Spectrum dual CCC [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-1477","post","type-post","status-publish","format-standard","hentry","category-case-studies"],"_links":{"self":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1477"}],"version-history":[{"count":6,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1477\/revisions"}],"predecessor-version":[{"id":1554,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=\/wp\/v2\/posts\/1477\/revisions\/1554"}],"wp:attachment":[{"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1477"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1477"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdr-separations.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}